BioSpine is a Griffith University-led research project aimed at restoring movement and sensation in people suffering from spinal cord injury. Overwhelming scientific evidence has demonstrated how the human nervous system can rewire itself, restoring both lost motor and sensory function. However, no rehabilitation therapy currently provides the adequate stimuli to the motor and sensory systems to enable rewiring. Our team is developing a disruptive rehabilitation system using advanced brain control and human machine interfaces, based on a digital twin of the patient's neuromusculoskeletal system, to provide all the appropriate motor and sensory stimuli to maximise neural plasticity and permanently restore the interrupted connection between the brain to the muscles. BioSpine Project is led by a cross-disciplinary team of scientists, engineers, allied health professionals and industrial designers at Griffith University, University of Sydney, and Harvard University. BioSpine is generously supported by the Motor Accident Insurance Commission, Perpetual IMPACT and Griffith University for 3 years.