The aim of our lab is to support basic, translational and clinical research pertinent to the 4R medicine (ie. Replace, Repair, Regenerate and Reprogram) related to skeleton diseases and aging. The skeleton diseases originates from developmental abnormalities, growth impairment, repair dysfunction, aging or acquired pathologies. Among these diseases, we are particularly interested in discovering new therapeutic strategies for osteoporosis, osteoarthritis, discarthrosis and periodontitis. Due to the increasing clinical situations where skeletal tissues are lost or compromised (bone, cartilage, teeth, disc..) we also focuse our research efforts on the use of stem cells, calcium phosphate ceramics and hydrogels for the development of reconstructive therapeutics. By formalizing an interdisciplinary approach, and providing researchers with a functional organizational structure, RMeS aims at offering a strong support and stimulating environment for exploring the limit of knowledge in 4R medicine.