There is a big difference in natural hormone replacement therapy methods, not only in the prescriptions themselves, but also in the delivery methods and the dosages recommended. Not every hormone replacement therapy (HRT) doctor offering bio identical hormone replacement therapy is an expert. Many doctors lack anything more than the rudimentary training and knowledge they acquired in medical school. What Is SottoPelle® In a word, balance. Hormonal balance is key to your well-being and a delicate thing to achieve. Other hormone replacement therapies rarely accomplish or maintain the hormonal equilibrium your body depends on for optimum health. With Sottopelle, your body can return to normal hormonal balance.