Computational Biomedicine is a key technology for better healthcare, agriculture and biotechnology. In particular, computational models linking bench and bedside are essential for the development of safe, efficient and personalized therapies of complex diseases. To realize the full potential of computational biomedicine, these models must address the complexity of medicine, integrating mechanistic aspects with big data analysis. At the interdisciplinary Joint Research Center for Computational Biomedicine (JRC-COMBINE), a joint venture of RWTH Aachen University, RWTH Aachen University Hospital, and Bayer AG we combine advanced modeling technologies and systems biology approaches with expertise from industry and academia to provide benefit for clinics, industry and society at large.