Value for Health CoLAB (VOH.CoLAB) is a nonprofit collaborative laboratory, whose mission is to help people and organisations to measure the value in health. The founding partners - Universidade NOVA de Lisboa, CUF, Fraunhofer Portugal, and Vodafone - have centralised competencies and resources to create this CoLAB to accelerate fundamental restructuring of Healthcare delivery towards a paradigm shift to Value-based Healthcare and patient empowerment. Our experience in digital transformation and technology transfer in the health sector, our closer working collaboration with people, health organisations (private and public) and universities, enable us to characterise, model and optimize health care trajectories. For this purpose, CoLAB supports academia, healthcare providers and medtech developers in: (i) collecting clinical and patient reported outcomes, with a focus on digital data collection processes and telemonitoring; (ii) implementing clinical pilots to measure economical and social impact of innovation in Health; (iii) developing digital health literacy tools that can drive society to adopt healthier behavioural changes. By following people longitudinally, whether in a hospital environment, at home or in specialised residential care, VOH.CoLAB aims to validate innovative methodologies for measuring objectively health outcomes and costs toward new Value-based Health models.