If left unchecked, drug-resistant bacteria will kill more people worldwide than cancer and diabetes combined. This also has the potential to result in a staggering economic loss forecasted at over $100 trillion. To begin to shield communities from this threat, we are introducing ARMADA—The Antibiotic Resistance Monitoring, Analysis and Diagnostics Alliance. ARMADA is the first-of-its kind reconnaissance approach to minimize the health impact of the bacterial resistance spread and preserve antibiotics for the future. ARMADA will use a nation-wide and global network of hospitals, doctor offices, veterinarians, scientists and citizen advocates to collect an unprecedented number of bacterial strains and detailed information about their antibiotic resistance profiles, genetic identity, and epidemiology.