The mission of the Learning Research and Development Center (LRDC) at the University of Pittsburgh is to advance the science of learning by bringing together leading researchers in the cognitive, social, and educational sciences. This mission has guided LRDC in its programs of basic and applied research, its demonstration projects, and its direct support of school improvement and reform. In LRDC’s multidisciplinary setting, scientists study learning in its cognitive, neural, social, and organizational aspects, making research and development links to formal education practice, policy, and out-of-school settings. Although the general mission of LRDC has remained constant, the center has pursued this mission by promoting research that evolves over time, informed by varied perspectives across multiple disciplines. LRDC’s research portfolio includes large programs of extended duration as well as single-investigator projects that are generally of smaller scope and shorter length.