TwInsight offers an online biomechanical modeling and simulation ecosystem providing access to high fidelity digital twins. Our models are based on a corpus of validated functional and structural anatomy. The TwInsight platform is made available for healthcare professionals as well as medical device industry (implants, orthotics, insoles) in order to: • promote better surgical outcomes through surgical planning optimization on an accurate digital twin of the patients created automatically from medical images and/or surfacic 3D scan, • promote better design of medical devices through in silico studies on virtual cohorts of simulated patients.