The TANGO2 Research Foundation's mission is to lead the way in finding a cure for TANGO2 related disease. We will do this by helping to fund, coordinate and guide scientific research that leads to a better understanding of how TANGO2 mutations affect people at the most basic cellular and biochemical pathway levels. TANGO2 as a gene related to human disease was first discovered in 2016. Rapid advances in technology and techniques such as Whole Exome Sequencing (WES) have allowed researchers to identify and catalog rare genetic disorders at a faster pace than ever before. What became very clear as we as parents and caregivers communicated with one another and learned more of each others unique experiences with our children and the medical community at large, is that not nearly enough was known about how it is that TANGO2 mutations affected our children at the most basic cellular, metabolic and biochemical level. The talented and caring professionals that were working so hard to help our children, lacked the benefit of this basic research and were doing the best they could with very limited research and data. This is where the idea for the TANGO2 Research Foundation was borne in late 2017. It is our hope that by helping to fund, coordinate and guide the efforts of researchers, scientists and doctors, we can rapidly accelerate the understanding around TANGO2 and pave the way to future therapies and positive outcomes for our loved ones.