The South Australian Genomics Centre (SAGC) was established in July 2020 as a State-wide genomics facility to support research in South Australia, as well as nationally and internationally. The SAGC is a partnership between the South Australian Health and Medical Research Institute (SAHMRI), University of South Australia, Flinders University, The University of Adelaide, the Australian Genome Research Facility (AGRF), and the Australian Wine Research Institute (AWRI). Its establishment was supported by an investment of >$7 million, including $2 million from BioPlatforms Australia (BPA). The SAGC central hub is located in the iconic SAHMRI building in the heart of Adelaide's Biomed City and has additional nodes on the Waite Campus and at Flinders University. The SAGC provides a broad range of services including RNA sequencing, small RNA sequencing, exome and genome sequencing, epigenomics, metagenomics, single cell genomics and a range of custom methods. These services are supported by a dedicated Bioinformatics Platform that support users of the facility by developing advanced and customised approaches for data analysis, integration and visualisation. The SAGC is pleased to support researchers and clinicians from all our partners institutes as well as industry partners and other external clients. All areas of genomics including animal, plant, environmental, microbial, and human genomics are supported.