Our mission is to make evidence syntheses more usable in every sense of the word – better designed, conducted and reported, more useable for decision makers and more usable within health care policy and clinical practice decision making across the Island of Ireland and beyond. We are building evidence synthesis knowledge, awareness and capacity among the public, health care institutions and policymakers, clinicians and researchers on the Island of Ireland. ESI includes Cochrane Ireland, whose mission is to promote evidence-informed health decision-making by producing high-quality, relevant, accessible systematic reviews and other synthesized research evidence.