HoliFAB is a EU Horizon 2020 project that aims to provide to microfluidics a holistic system-oriented and problem-solving approach, starting from the customer’s need, optimising the chip and addressing the question of its environment. This will tackle two main issues in microfluidics: - A considerable hindrance to fast prototyping and industrialisation, because system performances rely on complex selection and assembly of numerous fluidic, mechanic, optical, electronic (etc…) components - A complex process for setting the system requirements, because constraints and specifications of microfluidic systems cover a huge range in terms of complexity level, materials, dimensions, acceptable costs, without any standardisation and rationalisation of design and production