The Swiss Personalized Health Network is an initiative of the Swiss Government which contributes to the development, implementation and validation of coordinated data infrastructures in order to make health-relevant data interoperable and shareable for research in Switzerland. SPHN is led by the Swiss Academy of Medical Sciences (www.sams.ch) in collaboration with the SIB Swiss Institute of Bioinformatics (www.sib.swiss). The Management Office together with the SIB Personalized Health Informatics Group (PHI) coordinate the development of the SPHN initiative.