Equinox Pharma is a computationally-driven logic-based drug discovery company which, in partnership with pharma companies, agrochemical companies, biotechs and medicinal chemistry-based contract research organizations, uses its capability in proprietary logic-based machine learning and chemoinformatics (INDDEx™), based on the patented SV-ILP method (Patent number 8126823), to undertake drug discovery programmes for its clients. Equinox Pharma uses its proprietary logic-based machine-learning technique INDDEx™ (Investigational Novel Drug Discovery by Example) to learn from a training dataset of active and inactive molecules from a screening programme to generate quantitative logic-based rules. These rules provide vital chemical insight into the stereochemical and structural requirements for biological activity. Equinox then undertakes ligand-based virtual screening using the logic-based rules to search databases of commercially available, or proprietary, libraries of small molecules to identify potentially active molecules In contrast to other database screening tools, INDDEx™ is unique in the approach used such that the new structures identified, and predicted to be active, can bear little resemblance to the training data molecules. In this way INDDEx™ is a leading tool in scaffold-hopping technology. Reynolds, et al (2012). Assessment of a Rule-Based Virtual Screening Technology (INDDEx) on a Benchmark Data Set. J Phys Chem B 116, 6732-9.