Cultivate your business in Mesa, Arizona! With a population of more than 500,000 and part of Phoenix-Mesa metro, Mesa is the 37th largest city in the U.S., the 2nd largest city in the region, and covers 133 square miles (344 square kilometers). As a premier business destination, Mesa offers a diverse and sustainable economy, an educated workforce, a true partnership between government and industry, and business people who see Mesa as their home and the world as their marketplace. Discover how we can help your business grow in Mesa.