Over the past two decades, there has been a dramatic evolution in the manner through which cranial base pathologies are approached and managed. The development of the endoscope, stereotactic navigation systems, and innovative surgical techniques has facilitated the transition from traditional open surgeries to minimally invasive endoscopic approaches. Not only does this expansion in practice translate into an exciting time for skull-base surgeons, but it also offers the promise of a more streamlined approach to comprehensive patient care, improved patient satisfaction and experience, and superior outcomes.