The Foundation for Cardiovascular Research and Education (FCRE) was founded to conduct highly relevant investigator-initiated trials to address the unanswered questions in cardiovascular medicine as well as PMCF trials. To that end, the Foundation will focus on real-world trials to identify the best way to treat patients, targeting at improving or expanding existing therapies, separating responders from non-responders and eventually developing new reimbursement models. A network of high-quality medical centers, led by innovative and leading specialists, is ensuring the adequate volume and scientific rigor needed for relevant clinical studies.