The Upstate Carolina Consortium, an affiliate of the National Cancer Institute (NCI), engages community physicians to participate in NCI supported, cancer care delivery research, treatment, prevention and cancer control trials. Upstate Carolina Consortium serves a large rural, minority, and underserved population and is committed to increasing NCI clinical trial access and participation among this population that will reduce cancer disparities and the burden of cancer. Our Consortium’s goal is to support practice-changing cancer prevention, treatment and cancer control research that will improve patient outcomes and quality of life.