The INDRC, International Neurodegenerative Disorders Research Center, is a private, non-profit, global research institute based in Prague, Czech Republic, that for the first time combines biological sciences and medicine with big data and artificial intelligence approaches to study and treat Alzheimer’s disease and other neurodegenerative disorders. The INDRC goal is to merge and advance the globally dispersed knowledge in brain systems and neurodegeneration through research training fellowship programs of excellence, delivering outstanding independent research programs, building a world-class research community, and enabling technological and therapeutic innovations with genuine impact on society and humanity. INDRC is interdisciplinary by design, addressing research bottlenecks and developing new analytical approaches to discover and model the non-linear dynamics between biology, disease, man, and environment. The Institute uses a transparent governance model that includes committed international partners from European Union, North America and around the world, including universities, research institutes, clinical centers, and for-profit/non-profit companies. INDRC projects apply artificial intelligence and machine learning to address the challenges facing the identification and validation of new therapeutic interventions in Alzheimer´s and other neurodegenerative disorders to advance therapies with the greatest impact for patients.