A primary focus of our laboratory is the investigation of molecular mechanisms underlying polycystic kidney disease (PKD) and related renal diseases, and the development of new therapies. Research in the Weimbs Laboratory has already led to better understanding of aberrantly regulated signaling mechanisms in PKD and proposed possible new strategies for disease treatment. Our laboratory strives to discover new basic mechanisms of epithelial cell function and kidney physiology, and to translate these findings into the clinic. The training of future scientists at the postdoctoral, graduate and undergraduate level is another important mission of the Weimbs Laboratory.