The Center for Data-Driven Discovery in Biomedicine (D3b) at Children's Hospital of Philadelphia (CHOP) is founded on the premise that pediatric cancers and rare disease can serve as a central node of transformative biomedical and healthcare discovery. D3b focuses on the development of novel research and shared discovery platforms that support an interconnected ecosystem of stakeholders positioning patients as partners--as the most authentic of "data generators" empowering research and discovery. Our vision: Breakthroughs for every child, every time, everywhere Our Mission: To build and support a transformative healthcare discovery and education ecosystem providing innovative care for all children through collaborative, data-driven science