At ICN | Interventional and Cognitive Neuromodulation Charité, we are combining multimodal research methods including intraoperative invasive human neurophysiology (LFP and electrocorticography), non-invasive neurophysiology with magneto-/electroencephalography ( e.g. OPM ), structural and functional neuroimaging. Our projects explore how neural activity is synchronized across multiple nodes of the motor circuit, how such activity is implicated in cognition and neurological disorders and how these findings can be used for next-generation brain stimulation approaches for therapeutic translation. key research points are being tackled: -Functional relevance of oscillatory activity on cognitive and motor control . -Machine learning based real-time prediction of human behaviour from invasive recordings . -Mechanisms of synaptic plasticity in the pathophysiology of Parkinson’s disease . -Development of data science solutions for multimodal clinical neuroscience research data