EU based Smartomica has created a new philosophy for Personalized Medicine, aimed at making cutting edge science and advanced clinical experience available for medical practitioners in a way such that scientific data becomes clinically appropriate evidence. We design, build and deliver comprehensive  methodology to personalize each patients' profile through in-depth AI-based data analytics and translate the results to clinically applicable language in order to make it a practical tool for dedicated medical practitioners. Smartomica platform is designed to be integrated into regular clinical workflow to equip the physician with possible patient tailored scenarios built upon AI based analysis of existing scientific knowledge and clinical practice. Currently the platform development is focused on four clinical disciplines: cancer, autoimmune diseases, metabolic diseases, infertility.