OSIC – a global, 501(c)(3), not-for-profit cooperative effort between academia, industry and patient advocacy groups – was created to enable rapid, open source advances in the fight against idiopathic pulmonary fibrosis (IPF), fibrosing interstitial lung diseases (ILDs), and other respiratory diseases, including emphysematous conditions. global, data-rich repository of anonymized HRCT scans and clinical information regarding ILDs. The OSIC Data Repository currently houses close to 1,500 anonymized and quality-controlled scans with accompanying data, and has an additional 5,000 in the quality control queue. It is on track to reach its goal of 15,000 anonymized scans, available to OSIC members, by first quarter 2022. This first-of-its-kind database is the world’s largest and most diverse, with a plethora of real world clinical and imaging data that is both multi-ethnic and multi-center. Radiologists, clinicians, computational scientists, and industry competitors from around the world collaborated for almost three years on the development of the database itself, and are working together to advance digital imaging biomarkers for accurate imaging-based diagnosis, prognosis and prediction of response to therapy. Any OSIC-created algorithms will be made open source for the benefit of patients everywhere.