Virtual.PYXIS is a topology structural optimization software recommended for engineers and designers who need to design innovative components and assemblies with reduced mass. The software is able to handle from simple to complex optimization situations, also involving nonlinear analysis features (plasticity and contact) and compliant mechanism systems. The software has a state of art algorithm, which permits to achieve more weight reduction while keeping the same level of stiffness. Virtual.PYXIS has been created to fill the gap between academic research and what is available to the market. As it is solver independent, Virtual.PYXIS takes full advantage of the optimization potential and flexibility.