Envision a future of complete synergy between Nature and humanity, where human-made and Nature-grown become indistinguishable. OXMAN is a new kind of company fusing design, technology, and biology to invent multi-scale products and environments—allowing design to empower science and science to empower design. As activist designers, we call for a fundamental shift from human-centric design to Nature-centric design. Categorical delineations between climate change and global pandemics, loss of biodiversity and loss of empathy for one another give way to authoring systems that address manifold challenges. Through this shift, we open ourselves up to moving beyond mere maintenance of Nature toward its radical betterment.