Understanding and measuring biomolecular binding interactions remains a critical component of biochemical research, drug discovery, and diagnostics development. Despite enormous emphasis on collecting biologically relevant binding affinity data, many existing methods struggle to sensitively measure these interactions through chemical manipulation of one or more binding partner. Meru Biotechnologies’ Free Solution Analysis (FSA)combines the strengths of existing label-free approaches in a straightforward analytical platform, powered by advancements in Compensated Interferometry, which uses a single laser to measure experimental and reference samples in the same microfluidic channel simultaneously. FSA’s sensitivity rivals methods that use fluorescence and eliminates the need for surface immobilization strategies.