Fibroblasts are vital players in health and their dysfunction underlies numerous diseases. Mesintel has developed a proprietary target discovery platform that incorporates our extensive knowledge of fibroblast biology to accelerate the development of therapeutics in areas of high unmet medical need, including cancer and fibrosis. We are also leveraging our platform in complementary therapeutic areas, such as rare diseases, tissue regeneration and aging. Mesintel is decoding fibroblast biology at an unprecedented pace through the use of cutting-edge single cell multi-omics, human disease-informed genetically engineered models, cellular lineage tracing, functional genomics and sophisticated computational approaches, including AI/ML. Our discovery engine has yielded foundational insights into the mechanisms underlying fibroblast dysfunction and identified innovative therapeutic targets for modifying fibroblast activity to affect health and disease. We are seeking opportunities to propel collaborative discovery and development partnerships, and seed funding to advance internal programs and platform capabilities.