The Complex Systems & Security Lab within the Engineering Faculty of the University Campus Bio-Medico of Rome, is one of the leading research institutions in Homeland Security and Critical Infrastructure Protection (CIP) in Italy. In this field, research activities focus on the development of innovative and strong multi-disciplinary methodologies, tools and technologies to support the study of large infrastructures in terms of their behavior, threats, vulnerabilities and management. The group is marked by an innovative approach that combines theoretical research activities with practical technology solutions in a wide range of domains, such as automation technologies, industrial automation, control and robotics, biomedical engineering, computer science and, primarily, Critical Infrastructures. The group is also involved in several national and international research projects, recognized at an international level as a standard of excellence on subjects connected to Complex Systems, Homeland Security and Critical Infrastructures. The development of solutions that are not only efficient and effective but also safe and “acceptable” for the user and sustainable for the environment, is what distinguishes the COSERITY lab from others. In other words, the group applies tools of systems theory and automatic control to understand, model and influence the behavior of complex systems, whose elements are highly interconnected, in order to develop innovative solutions able to improve their functionality and features.