The Journal of Clinical Investigation (JCI) is a top-tier venue for discoveries in basic and clinical biomedical research that will advance the practice of medicine. Founded in 1924, the journal is published by the American Society for Clinical Investigation (ASCI). The JCI combines a 2020 Impact Factor of 14.808 with immediate free access to its research articles to produce an ideal home for authors seeking the widest possible audience for their most important work. The journal is headed by Editor in Chief Dr. Elizabeth M. McNally and an Editorial Board of peer scientists at Northwestern University. The JCI provides free access to all of its research articles.