ULTIMATE will act as a catalyst for “Water Smart Industrial Symbiosis” (WSIS) in which water/wastewater plays akey role both as a reusable resource but also as a vector for energy and materials to be extracted, treated, stored andreused within a dynamic socio-economic and business oriented industrial ecosystem. We adopt an evidence-basedapproach anchored on 9 large-scale demonstrations across Europe and SE Mediterranean relevant to the agro-foodprocessing, beverages, heavy chemical/petrochemical and biotech industries. We recover, refine and reuse wastewater(industrial and municipal) but also extract and exploit energy (combined water-energy management, treatmentprocesses as energy producers, water-enabled heat transfer, storage and recovery) and materials (nutrient miningand reuse, extraction and reuse of high-added-value exploitable compounds) contained in industrial wastewater. Wesupport the cases and ensure their replicability through smart tools to optimize and control, assess costs and benefits,minimize risks and help stakeholders identify, assess and explore alternative symbiotic pathways linked to emergingbusiness opportunities, supported by tailored contracts and investment schemes. ULTIMATE nurtures partnershipsbetween business (incl. industrial and technological ecosystems), water service providers, regulators and policymakers and actively supports them through immersive Mixed Reality storytelling using technology and art to co-produce shared visions for a more circular, profitable, socially responsible and environmentally friendly industry, withwater at its centre. The project mobilises a strong partnership of industrial complexes and symbiosis clusters, leadingwater companies and water service providers, specialised SMEs, research institutes and water-industry collaborationnetworks, and builds on an impressive portfolio of past and ongoing research and innovation, leveraging multiple European & global networks to ensure real impact. EU funding No 869318