MHRP is at the forefront of the battle against HIV. Our mission is to protect U.S. Service Members from HIV and improve global health by conducting research to develop an HIV vaccine, reduce new infections and advance strategies to induce long-term HIV remission. With an international network of research sites throughout Africa and Asia, the program’s growth and success has been achieved through a combination of strong science, careful development of research sites and partnerships with key research institutions in the U.S. and host countries. Since its inception in 1986, MHRP has emerged as a world leader in HIV vaccine research, threat assessment and epidemiology, HIV diagnostics and remission research. The integration of prevention and treatment through the President's Emergency Plan for AIDS Relief (PEPFAR) has helped MHRP build strong and trusting relationships within the communities where research is conducted and provides an ethical framework to conduct HIV clinical research. MHRP is centered at the Walter Reed Army Institute of Research (WRAIR), U.S. Army Medical Research and Materiel Command. Views presented here are not official views of the U.S. Department of Defense.