Humble Smile Foundation is a global group of dental and international development professionals who passionately promote oral health as an integral part of children’s well-being. Our mission is to help prevent suffering caused by oral diseases by developing and sharing effective and sustainable models of health promotion for communities with high unmet needs. We do this by managing and supporting oral and general health outreach projects that promote hygienic and healthy lifestyles. Our vision is children everywhere living healthy lives with healthy smiles. We envision a world, in which people take ownership of their health, and in which suffering caused by oral disease is minimized. In this world, dentistry leads the promotion of oral health and the prevention of oral diseases regardless of peoples’ socio-economic status, age, religion, gender, nationality, or geographical location. Even in the most remote areas of our planet, children have the option to live healthy lives and to go to school without oral health burdens. Humble Smile Foundation applies a holistic and human-centred design approach that is unique in each specific location. We develop innovative and effective models of oral and general health promotion that are culturally, socially and environmentally sensitive and provide sustainable solutions to the specific needs and circumstances of each community. Results are then shared broadly to be picked up by government or other executive players. Our work directly contributes to the UN’s Sustainable Development Goal 3: Ensuring healthy lives and promoting wellbeing for all ages. Furthermore, oral diseases are comorbidity factors in SDG3 targets including non-communicable and communicable diseases, sexual and reproductive health, and maternal and child health.