Cronos CCS, Inc. is a leading global provider of specialty clinical service solutions that combine science, technology, and innovation. We have an extensive risk-based data monitoring (RBDM) platform that allows us to proactively assess for potential risk prior to study initiation. These areas of risk may be mitigated by appropriate rater training and institution of in-study RBDM algorithms to identify issues and allow for them to be addressed in real-time. Our RBDM solution includes clinician involvement to review potential data issues in the larger context of a site’s performance, and to interact with raters to better understand data anomalies and provide critical guidance to prevent future recurrence. All of our service solutions are delivered with operational excellence, which may be further enhanced by our Cronos Independent Research Platform (CIRP) that simplifies scheduling, tracking and communication among all study vendors and resources. CIRP was developed specifically for pharmaceutical trials and features language localization, full Outlook integration, automated time-zone conversion, and role-based access levels. These proven solutions have resulted in demonstrable benefits to our clients, such as the ability to make evidence based decisions regarding site and rater actions (e.g., removal, initiation of a site visit), increased data integrity, and decreased financial burden.