The CARE Guidelines are health research reporting guidelines for case reports and available at www.care-statement.org or at www.equator-network.org. They have been translated into 10 languages and endorsed by multiple medical journals. Data collection from the point of care integrating clinical expertise with external evidence informs the delivery of high-quality individualized healthcare. “Good case reporting demands a clear focus, to make explicit to the audience why a particular observation is important in the context of existing knowledge.” (Vandenbroucke 2001) The CARE guidelines for case reports help authors reduce bias, increase transparency, and provide early signals of what works, for which patients, and under which circumstances.