Founded in 2007, the Singapore Institute for Clinical Sciences’ (SICS) mission is to promote health and human capacity in Singapore, Asia and globally. The first institute within the Agency for Science, Technology and Research (A*STAR) to focus on clinical sciences and translational research, SICS posits that health has its origins in good beginnings and continued interactions between our physiological makeup and environment. To fulfil our vision of building gateways and an evidence base for positive health, our institute strongly promotes clinical research that supports the understanding of metabolism, neuroscience and how they impact human development. To take our research into the real world, we launched seminal nationwide birth cohort studies such as Growing Up in Singapore Towards healthy Outcomes (GUSTO) and Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO). By paving the way for scientific research to make a difference to the social and economic fabric of our communities, we are committed to ‘Changing Tomorrow’s Health, Today’.