SIMSOFT HEALTHCARE makes use of multimodal user interfaces (speech recognition, voice synthetic, tactile surface and artificial intelligence) to stimulate and record all the cognitive functions of patients suffering from cognitive disease, similar to the Alzheimer disease. The use of these cognitive functions as biomarker of the disease enables to provide a reliable assistance to the primary care provider in its pathology evolution assessment functions. Since 2014, SIMSOFT HEALTHCARE carries a long time research effort for the development of the THALIE software application dedicated to the evolution following of the Alzheimer syndrome, using innovative technologies developed in the industrial domain to provide a reliable assistant to generalist medical practitioners. SIMSOFT HEALTHCARE is a brand of the SimSoft3D company, which is owned by its founders.