The Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT) is a joint public-private partnership between the Region of Sicily, through Civico and Cervello hospitals in Palermo, and UPMC, an integrated global health enterprise headquartered in Pittsburgh, USA, and one of the leading nonprofit health systems in the United States. The partnership has brought together resources, intellectual capital, and advanced technologies to offer state-of-the-art treatment. Over the past decade, ISMETT has become one of the leading organ transplant centers in Europe and a major referral center for other Mediterranean countries. More than 500 transplant procedures have been performed at ISMETT with outstanding clinical results. ISMETT's one-year survival rate for liver transplant recipients is the highest in Italy. At ISMETT, transplantation is not the only solution to end-stage organ failure and associated complex diseases. Specialized procedures include .surgical, radiologic, and endoscopic techniques and medical therapies to treat severe diseases and avoid transplantation. ISMETT’s specialists work closely with UPMC’s world-renowned transplantation teams and are supported by advanced diagnostic services, offering patients the most sophisticated therapies available. ISMETT collaborates with other major research centers in Italy and abroad, including the European Molecular Biology Laboratory in Monterotondo, the University of Palermo, the Italian National Research Council (Centro Nazionale delle Ricerche, CNR), the Zootechnological and Zooprophylaxis Experimental Institutes of Sicily, and the University of Miami’s Diabetes Research Institute. ISMETT also is associated with Sicily’s Micro- and Nano-Systems Technological Innovation Research Consortium. The Consortium promotes, implements, and manages research and training projects and encourages cooperation programs between Italian and international research organizations.