Psychedelics, which have been part of Indigenous/traditional healing practices for centuries, have enormous potential to address medical needs in the community and improve health outcomes. The Translational Psychedelic Research (TrPR) Program brings together scientists and care providers across disciplines to understand how psilocybin, LSD, ketamine, MDMA, and related compounds impact the brain and other organ systems. We combine innovative basic and clinical research approaches to answer key questions about the mechanisms, safety, and efficacy of psychedelics for specific health conditions. Our goal is to accelerate progress towards impactful and accessible psychedelic treatments. We’re committed to building a collaborative culture and applying open science principles to maximize the integrity and transparency of our work.