As Europe is facing the challenge of transforming into a fair and prosperous society, with a modern, re-source efficient and competitive economy, our business innovation ecosystems should be integrated around clusters, which actively support as agents of change the transformation of industry. The European Clusters Alliance is a bottom-up initiative that gathers 12 National Cluster Associations, representing more than 700 clusters, where 112.000 of our most innovative businesses collaborate with thousands of universities, research centers and public institutions to boost their competitiveness. Our mission is to be their common voice, facilitating connections and opportunities to meet the challenges they face. We call for the recognition of clusters as the most strategic agents in the next European programs: Single market program, Horizon Europe, Cohesion Policy and Digital Europe, reinforcing their presence in the Regional, Industrial and SME Strategies and introducing them in new initiatives currently under preparation, such as the Green Deal challenge or the Skills development where clusters as trust-based, collaborative innovation ecosystems can play a key role.