Clalit Innovation is responsible for the innovative use of Clalit's unique data and knowhow resources for improving the health and healthcare of its 4 million members. Clalit is the largest healthcare organization in Israel, and a global leader in implementing innovative strategies to tackle chronic illnesses. The research Institute comprises of professionals of multidisciplinary qualifications – top notch clinicians, epidemiologists, biostatisticians, IT experts, algorithm specialists and public health experts. Many of the institute associates are qualified in two or three of these disciplines, and have gained invaluable experience in mining and interpreting the organizational 'big-data' clinical (EMR-based) and administrative databases, that have been accumulating for almost two decades. The institute is augmented by its affiliates - leading clinicians from Clalit's 8 districts and 14 public hospitals that initiate and perform advanced studies with the support of the institute. The institute has focused in creating data-driven tools for enabling, supporting and assessing innovative clinical interventions to tackle key health and healthcare issues. These include including measuring and tackling inadequate treatment adherence, assessing and tackling the impact of NCDs and multi-morbidity, using predictive modeling and advanced analytics in the point of practice to allow targeted care in high risk groups, and comparative effectiveness real-life studies.