The EurOPDX Research Infrastructure (RI) aims to improve cancer drug development success rates through the enablement of collaborative PDX research. We are developing a user-friendly public repository to facilitate access to the +1500 PDX models from over 30 different cancer types currently curated by the EurOPDX Consortium. To enable effective PDX resource sharing, the project will develop common standards and procedures for PDX biobanking, quality control, and in vivo studies, and offer training in this area. These activities will enable to effective provision of free Trans-national Access (TA) to PDX resources and expertise for academic and industrial cancer researchers from Europe and Worldwide.