SiMPLInext SA acts in the field of advanced cell culture. Current conventional tissue models are unreliable to the point that they cannot be used as in vivo testing replacement. SiMPLInext provides a drop in replacement cell culture insert, which radically enhances the reliability, relevance, reproducibility, scope and quality of data acquired using in vitro models of biological barriers. Our inserts allow to culture better biological barriers, they allow to quality control their function in situ, and they collect the in situ measured data. This allows toxicologists and drug designers to better understand their biological barriers, without impacting processes or protocols.