The mission of the International Endotoxin and Innate Immunity Society (IEIIS), as that of the International Endotoxin Society that preceded the IEIIS, is to promote the exchange of ideas and new data among investigators of endotoxin biology and innate immunity and to support and promote the career development of our younger and more junior colleagues. Key to our society’s evolution has been the role that endotoxin-related research played in the discovery and characterization of innate immune recognition and response systems directed not just at Gram-negative bacteria but all microbe- and danger-associated perturbations of homeostasis.