In Silico Fermentation serves the biotechnology and biomedical industries by providing applied research, consulting services and educational training on microbial systems and processes. Our modeling expertise spans genome-scale metabolic reconstructions, microbial metabolism, biofilms, natural and engineered communities, stirred tank reactors and gas fermentation processes. Our novel workflow enables genome-scale metabolic reconstructions to be embedded within high fidelity simulation models of microbial communities and bioreactors. The same models used for detailed metabolic analysis of individual microbes can be integrated within larger scale models to understand community interactions and to predict bioreactor performance. Our expertise in the domain of microbial communities includes: 1. Multispecies biofilms – We have developed a novel modeling framework to predict spatial organization and metabolic interactions of microbes within multispecies biofilms. 2. Human gut microbiome – We have substantial experience developing and interrogating community metabolic models of the human gut microbiota. 3. Disease associated communities – We offer expertise in the the development of community metabolic models to perform in silico analyses of disease associated microbiota. Our expertise in the domain of biochemical reactors includes: 1. Gas Fermentation – We pioneered the use of genome-scale metabolic reconstructions to simulate gas fermentation reactors. 2. Mixed Microbial Cultures – We offer extensive experience developing and simulating mixed-culture bioreactor models for bioconversion applications. 3. Engineered Biofilms – We pioneered the development of biofilm metabolic models for renewable chemical synthesis.