Research at the Cambridge Stem Cell Institute falls under three key themes: Stem Cell States - studying the fundamental biology to understand the mechanisms by which stem cells self-renew, maintain their states, and differentiate to become different cell types. Stem Cells in Disease - investigating the mechanisms responsible for pathological behaviour of stem and progenitor cells. Stem Cells & Therapeutics - modelling diseases and generating new diagnostic and therapeutic approaches. With 28 Principal Investigators and 38 Affiliated Principal Investigators, the Cambridge Stem Cell Institute (CSCI) is central to a community of biologists, clinicians, and physical scientists working to better human health through stem cell research.