ST. FRANCIS COUNTY SHERIFF'S OFFICE Welcome to St. Francis County and the St. Francis County Sheriff's Office website. St. Francis County is located in East Central Arkansas, approximately 40 miles from the Mississippi River Bridge and Memphis, Tennessee, located on Interstate 40. We are very proud of our heritage, having been first discovered by Hernando DeSoto in the early 1500s. We are primarily agricultural related, having some of the richest farmland in the world to raise our cotton, soy beans, rice, wheat and corn. We also have peach orchards with the sweetest tasting peaches you'll ever find anywhere. Our population is around 30,000 with 610 square miles of area. Please come visit us anytime and allow yourself to be treated with real southern St. Francis County hospitality. We welcome you to St. Francis, and again, thank you for visiting our website.