The TMW Center for Early Learning + Public Health is an interdisciplinary research institute at the University of Chicago that advances a novel public health approach to prevent early cognitive disparities and achieve impact at scale. Science has identified parents and caregivers as key contributors to foundational brain development, but most early childhood efforts focus on children rather than the adults in their lives. Parents and caregivers are an untapped resource with the incentive and capacity to make a significant difference, which is why we put them at the center of our work to ensure all children thrive in their early years. We have developed a set of evidence-based interventions aimed at preventing disparities in foundational brain development. All TMW interventions share the goal of empowering parents and and caregivers with knowledge and skills to develop their children’s intellectual and educational potential. Each TMW intervention has been developed using rigorous innovation and continuous improvement cycles. Early results indicate they are effective at increasing caregivers’ knowledge and frequency of behaviors that utilize language to support young children’s brain development. But this is not enough. To reach as many children and families as efficiently and effectively as possible, the TMW Center is committed to developing new approaches to scaling and using rigorous scientific methods to ensure that parent and caregiver interventions yield strong outcomes in the real world.