The Personalized Lifestyle Medicine Institute (PLMI) is a not-for-profit entity whose mission is to transform healthcare through the promotion of information, innovation, and implementation of personalized lifestyle medicine. We will achieve our mission by cultivating virtual and in-person networks of collaboration among researchers, clinicians, patients, policy makers, and consumer advocates to bring personalized lifestyle medicine into greater visibility. Additionally, we will provide cutting-edge communication about the latest developments in personalized lifestyle medicine and case studies through our website and other educational endeavors. By harnessing the interest and input of individuals, thinkers, and innovative leaders, we will strive to be global leaders in this emerging field of healthcare.