SAFETY BY DESIGN® services and softwares are intended for the pharmaceutical, cosmetics and specialty chemicals fields. Harmonic Pharma places safety at the heart of the chemical design and innovation process to combine economic growth, human and environmental health. SAFETY BY DESIGN® allows : - Decipher a mechanism of action related to your compound of interest to guide towards the right market positioning. - Meet regulatory obligations (REACH/OECD). - Digitize and drastically reduce experimentation costs by limiting synthesis of substances, in vitro tests, in vivo tests and animal use. - To study products already on the market or at the research and development stage. The types of toxicological assessment available are Full safety evaluation with 10 independant QSAR models, Acute Toxicity, Carcinogenicity, Mutagenicity/genotoxicity (Statistical and Expert Rule-based models), Reprotoxicicity, Neurotoxicity, Respiratory sensitization, Endocrine disruption - Full model, Endocrine disruption - Statistical and Expert Rule-based models, Endocrine disruption - Estrogen receptor, Endocrine disruption - Androgen Receptor, Endocrine disruption - Thyroid Perturbation, Endocrine disruption – Steroidogenesis, Endocrine disruption - Aryl Hydrocarbon Receptor, Persistent, bioaccumulative and toxic (PBT) behavior, Eco-toxicity – Daphnea, Eco-toxicity - Algae, Eco-toxi 2022 innovation : SAFETY BY DESIGN®: real-time 3D service and software integrating the UNITY game engine and an Artificial Intelligence dedicated to the multidimensional investigation of chemical substances with predictive toxicology, analysis of mechanisms of action and associated scientific data (integrating Automatic Language Processing technology). SAFETY BY DESIGN® innovations : - Prediction of polypharmacological thresholds to categorize dangerous doses - Regulatory toxicology for human and environmental health. - Decision support for the design, development and substitution of chemical substances.